FIELD Study Revealed Fenofibrate Reduced Need for Laser Treatment for Diabetic Retinopathy
نویسنده
چکیده
A B S T R AC T P U R P O S E The FIELD (Fenofibrate Intervention and Event Lowering in Diabetes) study sought to investigate whether long-term lipid-lowering therapy with fenofibrate would reduce macroand microvascular complications among patients with type 2 diabetes. We previously reported that in type 2 diabetes patients with adequate glycemic and blood pressure control, a significant relative reduction was seen of almost one-third in the rate of first laser application for retinopathy after an average treatment duration of 5 years with fenofibrate 200 mg/day. In this report, we detail the effects of fenofibrate administration on ophthalmic microvascular complications and attempt to clarify some of the underlying pathologies being addressed among patients undergoing laser treatment. Supported by an unrestricted educational grant from Abbott Laboratories
منابع مشابه
Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial.
BACKGROUND Laser treatment for diabetic retinopathy is often associated with visual field reduction and other ocular side-effects. Our aim was to assess whether long-term lipid-lowering therapy with fenofibrate could reduce the progression of retinopathy and the need for laser treatment in patients with type 2 diabetes mellitus. METHODS The Fenofibrate Intervention and Event Lowering in Diabe...
متن کاملThe use of fenofibrate in the management of patients with diabetic retinopathy: an evidence-based review.
BACKGROUND Diabetic retinopathy is a significant cause of vision impairment, especially affecting those of working age. There are two large, randomised controlled trials examining the effect of fenofibrate on diabetic retinopathy. OBJECTIVE We summarise their findings, and report on the available safety data. DISCUSSION The FIELD study reported that patients treated with fenofibrate had a s...
متن کاملDiabetic retinopathy: treatment and prevention.
Diabetic eye disease is the major cause of blindness and vision loss among working-age people in developed countries. Microangiopathy and capillary occlusion underlie the pathogenesis of disease. While laser treatment is regarded as the standard therapy, intensive medical management of glycaemia and hypertension is also a priority in order to reduce the risk of diabetic retinopathy. Recent data...
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The drug fenofibrate has received major attention as a novel medical treatment for diabetic retinopathy (DR) and other diabetes-induced microvascular complications. This interest stems from two recent large, well-designed clinical trials that demonstrated large reductions in the progression of DR and the need for laser intervention, in addition to a reduction in renal and neurological outcomes,...
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